Road Trip Eats: 10 Italian Sub Chains You Shouldn’t Miss

There’s nothing like biting into a freshly made Italian sub when you’re hungry on the road. These sandwiches packed with meats, cheeses, and veggies are the perfect road trip fuel.
Whether you’re crossing state lines or just heading across town, these nationwide chains offer delicious Italian-style subs worth pulling over for.
Pack your appetite and check out these standout sandwich spots on your next journey.
1. Jersey Mike’s Subs

Started in 1956 on the Jersey Shore, this chain brings authentic East Coast flavor nationwide. Their Italian subs feature premium ingredients sliced fresh for each order, creating that distinctive deli experience.
What makes Jersey Mike’s special is their signature “Mike’s Way” preparation – a perfect balance of onions, lettuce, tomatoes, vinegar, oil and spices. The bread is the real star though, baked fresh in-store daily.
If you’re a first-timer, try their Original Italian packed with provolone, ham, prosciuttini, cappacuolo, salami and pepperoni. The cold cuts are sliced paper-thin right in front of you, ensuring maximum flavor in every bite.
2. Firehouse Subs Flavor

Founded by firefighter brothers, Firehouse Subs steams their meats and cheeses, creating a melt-in-your-mouth experience unlike any other chain. Their Italian sub, loaded with Genoa salami, pepperoni, ham, and provolone, delivers bold flavor with every bite.
The real magic happens with their signature toasted sub rolls, which hold up perfectly to their hot steamed fillings without getting soggy. Each restaurant features custom firefighter-themed murals and décor, adding character to your dining experience.
Did you know they donate a portion of each purchase to provide lifesaving equipment for first responders? Enjoying their Hook & Ladder or Italian sub helps support hometown heroes while satisfying your hunger.
3. Jimmy John’s Classics

Speed is Jimmy John’s superpower. When hunger strikes on a long drive, their “freaky fast” service gets fresh subs in your hands in minutes. Their Italian Night Club sandwich combines real genoa salami, Italian capicola, smoked ham, and provolone cheese on their famous French bread.
Jimmy’s bread recipe is a closely guarded secret, baked fresh throughout the day. The simplicity of their menu means they focus on doing a few things exceptionally well rather than offering endless options.
For road trips, their efficient wrapping technique keeps everything intact – no soggy bread or sliding ingredients. The 8-inch size is perfect for one hungry traveler, while the 16-inch can fuel you and a passenger for miles.
4. Penn Station East Coast

Hot and hearty describes Penn Station’s subs perfectly. Their Italian sub features smoked ham, hard salami, genoa salami, and provolone cheese, all grilled to melty perfection on freshly baked bread.
Though lesser known than some national chains, Penn Station has developed a cult following for their hand-cut fries cooked in peanut oil. These golden treasures make the perfect side to complement your Italian sub experience.
When ordering, don’t skip their freshly squeezed lemonade – it’s the ideal refreshing counterpoint to their savory subs. The open kitchen concept lets you watch as your sandwich is prepared, adding to the authentic experience that keeps road trippers coming back.
5. Capriotti’s Fan Favorites

Capriotti’s began in 1976 with a simple idea: roast whole turkeys overnight for the freshest sandwiches possible. While turkey made them famous, their Italian sub – called “The Capastrami” – has earned its own devoted following with hot pastrami, Swiss cheese, Russian dressing and homemade coleslaw.
Unlike many chains that use pre-sliced meats, Capriotti’s slow-roasts their meats in-house daily. This extra step creates a depth of flavor you can taste immediately.
Road trippers appreciate their substantial portion sizes that satisfy even the hungriest travelers. Their signature soft rolls perfectly contain the generous fillings without falling apart, making them ideal for eating on the go during your next road adventure.
6. PrimoHoagies Philly Style

If you’re looking for authentic Philadelphia-style Italian hoagies, PrimoHoagies delivers the real deal. Their sandwiches start with seeded Italian bread delivered fresh daily, creating the perfect foundation for their award-winning creations.
The “Italian” comes loaded with prosciutto, hot capicola, natural casing genoa salami, and sharp provolone – a combination that’s helped them expand from a single Philly shop to multiple states. Sharp provolone gives their hoagies a distinctive tangy kick that sets them apart from other chains.
When stopping during your road trip, try their signature “Primo” size – generous enough to satisfy but not so massive you’ll need a nap afterward. Their special oil blend with herbs and spices ties everything together for a truly memorable sandwich experience.
7. DiBella’s Italian Subs

Family-owned since 1918, DiBella’s has perfected their old-school Italian subs over generations. Their bread is the foundation of their success – crusty outside, soft inside, and baked throughout the day in stone-lined ovens.
The Godfather – their signature Italian sub – piles high-quality Genoa salami, capicola, spicy ham and provolone cheese with all the fixings. Though smaller than some national chains, DiBella’s loyal customers often drive miles out of their way during road trips just to grab their favorite sandwich.
First-timers should try the “Everything” option with oil, mayo, lettuce, tomatoes, onions, hot peppers, and their secret spice blend. The combination creates a flavor explosion that explains why this regional chain inspires such devotion among sandwich enthusiasts.
8. Lenny’s Grill & Subs

Hefty portions define the Lenny’s experience. Their regular subs measure 7.5 inches while their large subs stretch to a whopping 15 inches – perfect for sharing during long drives or satisfying serious hunger.
The Italian sub here features premium Genoa salami, ham, provolone, and capicola on freshly baked bread. What separates Lenny’s from competitors is their hand-sliced meats cut to order – thicker than typical delis for a more substantial bite.
Southern hospitality comes standard at all locations, making it a welcoming stop during cross-country journeys. Their proprietary hot pepper relish adds a unique kick that regulars swear by – ask for it on the side if you’re spice-curious but cautious about committing to the heat throughout your entire sandwich.
9. Erbert & Gerbert’s

Quirky sandwich names and a unique bread-hollowing technique make Erbert & Gerbert’s stand out from the crowd. Their Italian sub – called “The Comet Morehouse” – features ham, salami, and provolone on their signature bread.
Instead of slicing bread horizontally like most shops, they cut a V-shaped trench from the top and remove some of the soft interior. This creates a sturdy pocket that prevents fillings from falling out during your drive – practical genius for road trippers!
The removed bread piece (affectionately called the “guts”) comes alongside your sandwich as a bonus snack or dipping tool. Founded in Wisconsin in 1988, this Midwest favorite has gradually expanded while maintaining their unconventional approach to sandwich construction that makes them perfect for eating while on the move.
10. Milio’s Sandwiches Stop

Midwestern road trippers swear by Milio’s for their consistent quality and fresh-baked bread. Their Italian Club combines ham, capicola, salami, and provolone with a special blend of Italian seasonings that elevates the flavor profile.
Founded by a former Jimmy John’s employee who wanted to create his own sandwich legacy, Milio’s has developed a loyal following across Wisconsin, Minnesota, and Iowa. Their bread is baked fresh every four hours – a commitment to freshness you can taste with each bite.
When fuel stops align with Milio’s locations, try their signature potato chips made in-house daily. The combination of a freshly made Italian sub and crispy chips provides the perfect energy boost to keep you alert and satisfied for the next leg of your journey.